Genome Stability, Gene Diseases & Cancer (C7129)
Genome Stability, Genetic Diseases and Cancer
Module C7129
Module details for 2024/25.
15 credits
FHEQ Level 6
Module Outline
The design of new therapies for cancer depends on first understanding the molecular events that cause the disease. Genomic DNA is damaged spontaneously, by chemical carcinogens and by radiation. If unrepaired, this damage leads to mutations, cancer and other developmental disorders. All cells have evolved a sophisticated array of repair and response mechanisms to deal with DNA damage. The aim of this module is to understand the molecular mechanisms that control DNA repair and to appreciate how defects in genes involved in these repair processes are associated with different, in many cases cancer-prone, genetic disorders. Throughout the module, emphasis will be placed on the review and critical evaluation of recently published experimental evidence; advances in this area rely on a combination of biochemical analysis, genetic approaches and bioinformatics. Lectures will be complemented by discussion groups.
Module learning outcomes
Analyse the contribution of specific genetic changes to the development of cancer
Design experimental strategies to assess the potential relevance of DNA damage responses to cancer
Demonstrate a critical understanding of the molecular mechanisms behind the cellular response to DNA damage
Recognise how defects in DNA repair pathways contribute to the pathogenesis of DNA repair disorders
| Type | Timing | Weighting |
|---|---|---|
| Computer Based Exam | Semester 2 Assessment | 70.00% |
| Coursework | 30.00% | |
| Coursework components. Weighted as shown below. | ||
| Test | T2 Week 11 (1 hour) | 50.00% |
| Test | T2 Week 6 (1 hour) | 50.00% |
Timing
Submission deadlines may vary for different types of assignment/groups of students.
Weighting
Coursework components (if listed) total 100% of the overall coursework weighting value.
| Term | Method | Duration | Week pattern |
|---|---|---|---|
| Spring Semester | Seminar | 1 hour | 00100010010 |
| Spring Semester | Lecture | 1 hour | 22222222222 |
How to read the week pattern
The numbers indicate the weeks of the term and how many events take place each week.
Dr Owen Wells
Convenor, Assess convenor
/profiles/260574
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