Regulating Gene Expression (C7132)
Regulating Gene Expression
Module C7132
Module details for 2022/23.
15 credits
FHEQ Level 6
Module Outline
This module takes a current perspective of the molecular mechanisms controlling RNA expression in eukaryotes, focusing largely on gene transcription and translation but also RNA processing and regulation by non-coding RNAs. We will explore how eukaryotic transcriptional regulators control RNA polymerase recruitment and retention and modulate chromatin structure during transcriptional activation and repression. The module will also focus on mechanisms of post-transcriptional gene control and protein translation. Understanding these processes and mechanisms is fundamental for our understanding of the regulation of normal cell growth and how it can become deregulated in diseases including cancer.
Module learning outcomes
Describe the factors and molecular mechanisms involved in the regulation of transcription, RNA processing and nuclear export.
Describe the mechanism of translation and how this process is modulated by growth factors, nutrients and in disease.
Describe the role of non-coding RNAs in gene regulation and the consequences of their deregulation in disease.
Utilise information extracted from the relevant scientific literature.
Describe key scientific techniques used to study gene expression and interpret and analyse data obtained using these techniques
| Type | Timing | Weighting |
|---|---|---|
| Coursework | 30.00% | |
| Coursework components. Equal weighting for all components. | ||
| Essay | T1 Week 11 | |
| Computer Based Exam | Semester 1 Assessment | 70.00% |
Timing
Submission deadlines may vary for different types of assignment/groups of students.
Weighting
Coursework components (if listed) total 100% of the overall coursework weighting value.
| Term | Method | Duration | Week pattern |
|---|---|---|---|
| Autumn Semester | Lecture | 1 hour | 22222222222 |
| Autumn Semester | Seminar | 2 hours | 00100100100 |
How to read the week pattern
The numbers indicate the weeks of the term and how many events take place each week.
Dr Leandro Castellano
Assess convenor, Convenor
/profiles/437664
Dr Benjamin Towler
Assess convenor
/profiles/247980
Prof Michelle West
Assess convenor
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