Neuronal Plasticity and Gene Regulation (C1121)
Neuronal Plasticity and Gene Regulation
Module C1121
Module details for 2012/13.
15 credits
FHEQ Level 6
Module Outline
This module will consider how cellular and molecular mechanisms interact in the regulation of neural functions underlying plasticity. Particular emphasis will be placed on mechanisms that mediate the acquisition, processing and storage of information by the nervous system. The role of unconventional neurotransmitters such as endogenous nitric oxide and endocannabinoids in neuronal plasticity will also be discussed. This will be followed by lectures on unconventional molecular mechanisms controlling gene expression in the CNS. Specifically, we will review the recent advances in our understanding of how epigenetic regulation and non-coding RNAs contribute to functional plasticity in the nervous system.
Pre-Requisite
Biochemistry students taking this module will not be able to select the formal pre-requisite, however the core module, Principles of Neuroscience, will be fine in place of NTT for these students
Module learning outcomes
Demonstrate a knowledge and systematic understanding of the role of molecular and macromolecular structures in synaptic plasticity and memory
Appreciate the role of epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNAs) in normal and pathological conditions in the brain
Demonstrate the ability to review and critically evaluate current research on the role of molecular mechanisms in specific types of neuronal plasticity
| Type | Timing | Weighting |
|---|---|---|
| Unseen Examination | Semester 2 Assessment | 75.00% |
| Coursework | 25.00% | |
| Coursework components. Weighted as shown below. | ||
| Essay | T2 Week 11 | 100.00% |
Timing
Submission deadlines may vary for different types of assignment/groups of students.
Weighting
Coursework components (if listed) total 100% of the overall coursework weighting value.
| Term | Method | Duration | Week pattern |
|---|---|---|---|
| Spring Semester | Lecture | 1 hour | 222222222220 |
How to read the week pattern
The numbers indicate the weeks of the term and how many events take place each week.
Dr Sergei Korneev
Assess convenor, Convenor
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